Neuroprotective effect of neuroserpin in non-tPA-induced intracerebral hemorrhage mouse models
نویسندگان
چکیده
منابع مشابه
Neuroprotective effect of neuroserpin in non-tPA-induced intracerebral hemorrhage mouse models
BACKGROUND The neuroprotective effects of neuroserpin (NSP) have been well documented in both patients and animal models with cerebral ischemia; however, have never been investigated in hemorrhagic stroke. The aim of this study is to verify the neuroprotection of NSP in the non-tPA-induced intracerebral hemorrhage (ICH) mouse model. METHODS C57BL/6J male mice (n = 198) were involved in this s...
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15 صفحه اولRodent models of intracerebral hemorrhage.
The collagenase and whole blood intracerebral hemorrhage (ICH) models are widely used to identify mechanisms of injury and to evaluate treatments. Despite preclinical successes, to date, no treatment tested in phase III clinical trials has benefited ICH patients. These failures call into question the predictive value of current ICH models. By highlighting differences between these common rodent...
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Intracerebral hemorrhage (ICH) is associated with higher mortality and morbidity than any other form of stroke. However, there currently are no treatments proven to improve outcomes after ICH, and therefore, new effective therapies are urgently needed. Growing insight into ICH pathophysiology has led to the development of neuroprotective strategies that aim to improve the outcome through reduct...
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After intracerebral hemorrhage (ICH), the brain parenchyma is exposed to blood containing red blood cells (RBCs) and consequently to its lysis products. Iron-rich hemoglobin (Hb) is the most abundant protein in RBCs. When released into the brain parenchyma during hemolysis, Hb becomes a central mediator of cytotoxicity. Our study indicates that haptoglobin (Hp), an acute-phase response protein ...
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ژورنال
عنوان ژورنال: BMC Neurology
سال: 2017
ISSN: 1471-2377
DOI: 10.1186/s12883-017-0976-1